What is Opioid Withdrawal?

Key Points:

  • Opioid withdrawal is a physiological response to the absence of opioids.

  • It is indicative of physical dependence on opioids.

  • Withdrawal can occur with both prescription and illicit opioid use.


Opioid withdrawal occurs when an individual who has been using opioids for a prolonged period reduces or stops their intake. This process can trigger a range of physical and psychological symptoms as the body adjusts to the absence of the drug. Opioids include both prescription medications, such as oxycodone, hydrocodone, and morphine, as well as illicit drugs like heroin. Withdrawal is a clear sign of physical dependence on opioids, where the body has adapted to the presence of the drug and struggles to function normally without it.

When opioids are taken regularly, the body becomes accustomed to their effects, including pain relief, euphoria, and sedation. Over time, the body reduces its own production of certain neurotransmitters, such as endorphins, which naturally manage pain and mood. This adaptation means that when opioid use is suddenly reduced or stopped, the body is left in a state of imbalance, causing withdrawal symptoms as it attempts to restore normal function.

Causes of Opioid Withdrawal

Opioid withdrawal can occur for several reasons, including:

  • Intentional Cessation: When a person decides to quit opioids, whether on their own or under medical supervision.

  • Involuntary Cessation: Situations where opioids are no longer available, such as during incarceration or due to supply issues.

  • Dose Reduction: When a person reduces their opioid intake, either deliberately or because of prescription changes.

Read More:

  • Symptoms of Opioid Withdrawal

  • Stages of Opioid Withdrawal

  • Timeline of Opioid Withdrawal