Key Points:

• The timeline can vary significantly based on individual factors.

• Peak symptoms usually occur within the first 72 hours.

• Long-term management may be necessary to address PAWS.

The timeline for opioid withdrawal varies depending on factors like the type of opioid used, the duration of use, and the individual's physiology. Here's a general overview:

• First 24 Hours:

  • Anxiety, restlessness, and muscle aches begin.

  • Symptoms gradually increase in intensity.

• Days 2-3:

  • Symptoms peak, including severe muscle pain, sweating, nausea, and vomiting.

  • This is often the most challenging period.

• Days 4-7:

  • Symptoms start to diminish in intensity.

  • Physical symptoms like nausea and aches reduce, but psychological symptoms like depression and cravings may persist.

• Weeks 2-4:

  • Most acute physical symptoms subside.

  • Psychological symptoms like anxiety and mood swings may continue.

• Beyond 1 Month:

  • PAWS can occur, with intermittent symptoms.

  • Long-term support is often necessary to manage these lingering effects.